In addition, pregnant and lactating women, and those with severe central nervous system, hepatic, and renal problems, were excluded from the study. Patients who had received any antiscabietics or topical steroids during the past 4 weeks were excluded. provided the medications free of charge to all the patients and their family contacts.Ĭase selection From December 2002 to October 2003, all consecutive patients with scabies who were older than 5 years of age and attending the dermatology outpatient department of Razi Hospital were admitted. The drugs were prepared and packaged in identical-appearing tubes and randomized and coded by the manufacturer (Gilaranco, Rasht-Iran). Because of the relatively high prevalence of scabies in northern Iran and owing to the lack of information about the efficacy of permethrin in the treatment of scabies in our area, an investigation was carried out to find the best insecticide in the control and management of scabies in northern Iran during the year 2003. Currently, 5% topical permethrin cream is considered by many as the drug of choice in the treatment of scabies. There are some reports of rising resistance to this drug. There are many antiscabietic drugs in Iran, the most commonly prescribed one being the organochloride insecticide lindane. Scabies is considered as a major public health problem in developing countries, including Iran. Conclusion: Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment. Permethrin provided an improvement rate of 84.6% after two weeks, whereas lindane was effective only in 48.9% of patients. Results: Of the 99 patients enrolled in the study, 47 patients received 1% lindane cream, and 52 patients were treated topically with 5% permethrin cream. Subsequently, patients were followed up at 2- and 4-week post-treatment. One group and their family contacts received 1% lindane cream, and the other group and their family contacts were treated with topical 5% permethrin cream. Methods: In a double-blind, randomized study, all consecutive patients with scabies were randomized into two groups. Aim: To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran. Abstract Background: Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran.
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